I. Ozi Basic
Aha mkpokọta: Semaglutide
Ụdị: GLP-1 agonist nnabata (glucagon-dị ka peptide-1 analọgụ ogologo oge)
Usoro nchịkwa nke oge: injection subcutaneous (otu ugboro kwa izu)
II. Ngosipụta na Ọkwa Nkwenye Ụlọ
Ngosipụta akwadoro
Ụdị ọgwụgwọ ọrịa shuga 2 (NMPA kwadoro):
Usoro onunu ogwu: 0.5 mg ma ọ bụ 1.0 mg, otu ugboro kwa izu.
Omume: Na-achịkwa glucose ọbara ma na-ebelata ihe ize ndụ nke obi.
Ọgwụgwọ oke oke/oke oke
III. Usoro nke Omume na arụmọrụ
Isi Mechanism: Na-eme ka ndị na-anabata GLP-1 rụọ ọrụ, na-egbu oge mkpofu afọ, ma na-abawanye satiety.
Na-arụ ọrụ na etiti agụụ hypothalamic, na-egbochi agụụ.
Na-eme ka mmetụta insulin dịkwuo mma ma na-achịkwa metabolism.
Mbelata ịdị arọ (Dabere na ule ụlọ ọgwụ mba ụwa):
Nkezi ịdị arọ ọnwụ karịrị izu 68: 15%-20% (na njikọ na ntinye ndụ).
Ndị ọrịa na-enweghị ọrịa shuga (BMI ≥ 30 ma ọ bụ ≥ 27 nwere nsogbu):
Ndị ọrịa na-arịa ọrịa shuga: Mmetụta mbelata ibu dị ntakịrị (ihe dị ka 5%-10%).
IV. Ọdabara Population na Contraindications
Ndị Ọdabara
Ụkpụrụ mba ụwa (na-ezo aka na WHO):
BMI ≥ 30 (obese);
BMI ≥ 27 nwere ọbara mgbali elu, ọrịa shuga, ma ọ bụ ọrịa metabolic ndị ọzọ (oke ibu).
Omume Ezinụlọ: Na-achọ nyocha dọkịta; A na-eji ya ugbu a maka njikwa ibu na ndị ọrịa mamịrị.
Contraindications
Akụkọ nke onwe ma ọ bụ ezinụlọ nke medullary thyroid carcinoma (MTC);
Otutu endocrine neoplasia syndrome ụdị 2 (MEN2);
Ụmụ nwanyị dị ime ma ọ bụ na-enye nwa ara;
Ọrịa eriri afọ siri ike (dịka akụkọ ihe mere eme nke pancreatitis).
V. Mmetụta na ihe ize ndụ
Mmetụta emetụtakarị (omume> 10%):
Ọgbụgbọ, vomiting, afọ ọsịsa, afọ ntachi (belata na iji ogologo oge).
Mbelata agụụ, ike ọgwụgwụ.
Ihe ize ndụ dị egwu:
Ụbụrụ C-cell thyroid (ihe ize ndụ egosipụtara na ọmụmụ anụmanụ, amabeghị n'ime mmadụ);
pancreatitis, ọrịa gallbladder;
Hypoglycemia (a na-akpachara anya mgbe ejiri ya na ndị nnọchi anya hypoglycemic ndị ọzọ).
VI. Ihe eji eme ugbu a na China
Ụzọ inweta:
Ọgwụgwọ ọrịa shuga: Ndenye ọgwụ sitere n'ụlọ ọgwụ nkịtị.
Ọgwụgwọ Mbelata ibu: chọrọ nyocha siri ike nke dọkịta; ngalaba endocrinology ụlọ ọgwụ ụfọdụ nwere ike ịnye ya iwu.
Ihe ize ndụ sitere na ọwa na-akwadoghị: Ọgwụ ndị a zụtara site na ọwa na-akwadoghị nwere ike ịbụ adịgboroja ma ọ bụ echekwara nke ọma, na-ebute ihe egwu nchekwa.
VII. Atụmatụ ojiji
Soro ndenye ọgwụ dọkịta: Jiri naanị mgbe dọkịta nyochachara ihe ngosi metabolic na akụkọ ahụike ezinụlọ.
Ntinye aka n'ụdị ndụ jikọtara ọnụ: Ọ dị mkpa ijikọ ọgwụ na njikwa nri na mmega ahụ iji nweta nsonaazụ kacha mma.
Nleba anya ogologo oge: Na-enyocha ọrụ thyroid mgbe niile, enzymes pancreatic, na imeju na akụrụ ọrụ.
Oge nzipu: Nov-03-2025